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Researchers say a person with no family history of colorectal cancer who has a “negative” initial high-quality colonoscopy can probably wait longer than a decade for a second exam. Getty Images
  • In a new study, researchers say people who show no signs of colorectal cancer during an initial colonoscopy can probably wait longer than 10 years for their next exam.
  • Experts say the longer wait can work if the colonoscopy was a high-quality test and the person has no family history of the disease.
  • Other experts, however, say there is risk in waiting longer than 10 years because colonoscopies can miss polyps that can later turn into cancerous cells.

You might not need to get a colonoscopy every 10 years if your last exam was clean.

That’s because people who check out as “negative” on a high-quality colonoscopy enjoy a significantly lower risk of colorectal cancer (CRC) incidence for well beyond a decade after screening, a new study says.

American Cancer Society recommendations call for routine colonoscopies — a camera-assisted examination of the lower bowel — every 10 years for average-risk adults, beginning at age 45.

“An average-risk adult is defined as someone who does not have a family history of CRC or polyps, a personal history of CRC, or a personal history of chronic inflammatory bowel disease such as ulcerative colitis or Crohn’s disease,” noted Dr. David Samadi, director of men’s health and urologic oncology at St. Francis Hospital in Roslyn, New York.

But researchers from The Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Poland, said their findings “suggest that the currently recommended 10-year interval for screening colonoscopy is safe and could potentially be extended.”

“Our findings confirm that the 10-year interval between high-quality screening colonoscopies is safe and there is no benefit from more frequent screening,” Dr. Nastazja Pilonis, a study author who works in the department of gastroenterology at the Institute, told Healthline. “Furthermore, the findings suggest that this interval could even be prolonged… if and only if we are sure that all endoscopies are high-quality.”

Dr. Seth David Rosen, a gastroenterologist at the Miami Cancer Institute in Florida, told Healthline that high-quality “means an adequate preparation of the colon to visualize polyps as well as an appropriately trained and experienced endoscopist with a track record of finding polyps in at least 20 percent of the routine screening colonoscopies they perform.”

The study, published in the Annals of Internal Medicine, found that a negative screening was associated with a 72 percent reduction in colorectal cancer risk and a 81 percent reduction in death from the disease for up to 17 years.

“The risk of colorectal cancer and colorectal cancer death remains very low and stable throughout the entire 17.4 years of observation,” said Pilonis.

Researchers drew their conclusions from data gleaned from 165,887 individuals in a colonoscopy screening registry. They looked at risk and mortality of colorectal cancer following negative results on low-quality and high-quality colonoscopies.

The authors stressed that the study demonstrated that high-quality colonoscopies are highly effective in detecting colorectal cancer, including among women.

“Previous studies had shown that women do not benefit from screening colonoscopies as much as men,” said Pilonis. “We also observed this difference in our results when we considered all performed colonoscopies. However, when we looked at high-quality colonoscopies only, we observed that the risk of CRC was the same for both women and men.”

“The findings from this study should help physicians to feel confident of following the recommended guidelines of 10-year rescreening intervals after a normal colonoscopy,” Samadi told Healthline. “This study also shows the importance of a high-quality colonoscopy that could extend the rescreening intervals to be more than every 10 years.”

Dr. Jesse P. Houghton, senior medical director of gastroenterology at Southern Ohio Medical Center Gastroenterology Associates, cautioned that colonoscopies are difficult to perform and far from foolproof.

“There is a reported ‘miss rate’ of up to 15 percent of adenomas during a colonoscopy, if we take all colonoscopies together,” Houghton told Healthline. “Most gastroenterologists would not feel comfortable never performing another colonoscopy after a reported ‘normal exam’ due to these factors. Until we have more data than this one study, I would not suggest changing our recommendations from our governing bodies.”

“The ideal screening and surveillance intervals continue to be debated,” said Dr. Jeffery Nelson, FACS, FASCRS, surgical director at The Center for Inflammatory Bowel and Colorectal Diseases at Mercy Medical Center in Baltimore. “The American Cancer Society recently dropped the age at which they recommend people to begin screening… from age 50 to age 45 because of the increase of colorectal cancers being seen in patients in their early to mid-fifties. We know it takes 10 to 15 years for polyps to turn into cancers, so beginning screening earlier could catch these polyps.”

Nelson told Healthline that, by itself, the study “should not be practice changing, but serve as the impetus for designing more rigorous prospective studies that can adequately test the hypothesis that screening intervals in the average risk person could be lengthened under certain circumstances.”

“Only then could the strategy be applied more broadly to the general population,” he said.

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